Anticipation in Lynch Syndrome: Where We Are Where We Go

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Anticipation in Lynch Syndrome: Where We Are Where We Go

Lynch syndrome (LS) is the most common form of inherited predisposition to develop cancer mainly in the colon and endometrium but also in other organ sites. Germline mutations in DNA mismatch repair (MMR) gene cause the transmission of the syndrome in an autosomal dominant manner. The management of LS patients is complicated by the large variation in age at cancer diagnosis which requires these...

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ژورنال

عنوان ژورنال: Current Genomics

سال: 2011

ISSN: 1389-2029

DOI: 10.2174/138920211797904070